4-Nitroanthranilic acid → 4-Nitro-isatoic anhydride

HRID 1175788ノート

反応式

HRID 1175788 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([NH2:13])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9])([O-:3])=[O:2].Cl[C:15](Cl)([O:17]C(=O)OC(Cl)(Cl)Cl)Cl>O1CCCC1>[N+:1]([C:4]1[CH:12]=[CH:11][C:7]2[C:8](=[O:10])[O:9][C:15](=[O:17])[NH:13][C:6]=2[CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 120764-Nitroanthranilic acidHCID 94429Triphosgene

生成物 1

HCID 2820894-Nitro-isatoic anhydride収率 20,285.801%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
45 °C

実験手順

A mixture of 4-nitroanthranilic acid (9.11 g), triphosgene (4.92 g) and tetrahydrofuran (240 ml) was stirred for 10 hours at 45° C. The precipitated solids were collected by filtration, washed with tetrahydrofuran, and then dried to obtain the target product (700 g).

後処理

  1. filtrationThe precipitated solids were collected by filtration
  2. washwashed with tetrahydrofuran
  3. customdried

出典と根拠

ORDレコード
ord-02042def898647ecb57e7d9c13f875cd
出典データセット
uspto-grants-2010_11
特許番号
US07842701B2

反応ノート

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