Dextrorphan hydrobromide → Dextrorphan

HRID 1244213ノート

反応式

HRID 1244213 の反応式
[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1.Br>C(#N)C.[N+]([O-])([O-])=O.[Ag+]>[CH3:1][N:2]1[C@H:11]2[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=3[C@:5]3([C@@H:10]2[CH2:9][CH2:8][CH2:7][CH2:6]3)[CH2:4][CH2:3]1

参加物

4

反応物 1

HCID 12309240Dextrorphan hydrobromide

生成物 1

HCID 5360697Dextrorphan

試薬・触媒・溶媒 2

HCID 24470Silver Nitrate触媒HCID 6342Acetonitrile溶媒

実験手順

The salt is prepared by adding silver nitrate (0.50 g, 2.96 mmoles) to a solution of Dextrorphan hydrobromide (1 g, 2.96 mmoles) in acetonitrile (17 ml). The solution is then stirred at room temperature for 30 minutes. Filtering is then effected to remove silver bromide precipitate. The clear solution is added of ethyl ether (100 ml). A precipitate is formed, that is filtered, washed with ethyl ether and dried under vacuum. The solid obtained at the elemental analysis corresponds to the nitrate salt of Dextrorphan:

後処理

  1. customThe salt is prepared
  2. filtrationFiltering
  3. customto remove silver bromide precipitate
  4. additionThe clear solution is added of ethyl ether (100 ml)
  5. customA precipitate is formed
  6. filtrationthat is filtered
  7. washwashed with ethyl ether
  8. customdried under vacuum

出典と根拠

ORDレコード
ord-ceea208177d7411a81d584ecab9228dd
出典データセット
uspto-grants-2006_10
特許番号
US07122539B2

反応ノート

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