Acetone → 1-(Isocyanatomethyl)-4-nitrobenzene

HRID 1244481ノート

反応式

HRID 1244481 の反応式
[Cl-].[N+:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11]C(O)=O)=[CH:7][CH:6]=1)([O-:4])=[O:3].[N-:15]=[N+]=[N-].[Na+].C[C:20](C)=[O:21]>C(Cl)(Cl)Cl>[N+:2]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][N:15]=[C:20]=[O:21])=[CH:9][CH:10]=1)([O-:4])=[O:3]

参加物

6

反応物 4

HCID 180AcetoneHCID 312ChlorideHCID 4661(4-Nitrophenyl)acetic acidHCID 33557Sodium Azide

生成物 1

HCID 111480481-(Isocyanatomethyl)-4-nitrobenzene

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
0 °C

実験手順

The chloride of 4-nitrophenylacetic acid in solution in dry acetone (7.5 ml) is slowly added to an aqueous solution of 0.75 g (11.5 mmoles) of sodium azide, cooled down to 0° C. Agitation of the medium is maintained for one hour after the addition is completed, at 0-5° C. The reaction medium is then diluted with 30 ml of chloroform, decanted and the organic phase washed with water (20 ml) followed by a saturated solution of sodium chloride (20 ml). After drying over sodium sulphate, the organic solution is filtered and partly concentrated (* 20 ml) under vacuum.

後処理

  1. temperatureAgitation of the medium is maintained for one hour
  2. additionafter the addition
  3. customis completed, at 0-5° C
  4. customdecanted
  5. washthe organic phase washed with water (20 ml)
  6. dry with materialAfter drying over sodium sulphate
  7. filtrationthe organic solution is filtered
  8. concentrationpartly concentrated (* 20 ml) under vacuum

出典と根拠

ORDレコード
ord-5bde7b34ab444cdc8b8a0738703ffac9
出典データセット
uspto-grants-2006_10
特許番号
US07122535B2

反応ノート

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