Sodium Carbonate → HCID 67159074、化合物

To a cooled (−78° C.) solution of 4-trifluoromethyl cyclohexanone (3.00 grams, 18.1 mmol) in anhydrous THF (100 mL) was added lithium bis(trimethylsilyl)amide (19.9 mL, 1.0 M in THF, 19.9 mmol) dropwise. After 10 min, a solution of 2-[N,N-bis(trifluoromethylsulfonyl)amino]5-chloropyridine (7.09 g, 18.1 mmol) in THF (20 mL) was added, and the resulting mixture was allowed to warm slowly to ambient temperature overnight, at which point it was quenched by pouring into sat. aq. NaHCO3. The mixture was extracted with EtOAc. The organic phase was separated, dried over anhydrous sodium sulfate, and concentrated in vacuo. The resulting enol triflate was used without further purification. To a flask containing the unpurified enol triflate were added 4-ethoxycarbonylphenylboronic acid (3.68 g, 18.69 mmol) and trans-dichlorobis(triphenylphosphine) palladium (II) (633 mg, 0.903 mmol). Acetonitrile (90 mL) and sodium carbonate (45 mL, 1.0 M aqueous, 45.0 mmol) were added, and the resulting mixture was degassed via nitrogen sparge. The reaction mixture was stirred at 70° C. for 1.5 h, then was allowed to cool to room temperature and was poured into water. The mixture was extracted with EtOAc, and the organic phase was concentrated in vacuo. Purification by chromatography on silica gel (0 to 10% EtOAc in hexanes, then 10 to 100% EtOAc) provided the title compound: LCMS m/z 299.5 [M+H]+; 1H NMR (500 MHz, CDCl3) δ 7.99 (d, J=8.5 Hz, 2H), 7.42 (d, J=8.5 Hz, 2H), 6.20-6.18 (m, 1H), 4.37 (q, J=7.0 Hz, 2 H), 2.61-2.18 (m, 6H), 1.74-1.68 (m, 1H), 1.39 (t, J=7.0 Hz, 3H).

1. customwas quenched
2. additionby pouring into sat. aq. NaHCO3
3. extractionThe mixture was extracted with EtOAc
4. customThe organic phase was separated
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated in vacuo
7. customThe resulting enol triflate was used without further purification
8. additionTo a flask containing the unpurified enol triflate
9. customthe resulting mixture was degassed via nitrogen
10. customsparge
11. temperatureto cool to room temperature
12. additionwas poured into water
13. extractionThe mixture was extracted with EtOAc
14. concentrationthe organic phase was concentrated in vacuo
15. customPurification by chromatography on silica gel (0 to 10% EtOAc in hexanes

ORDレコード

ord-353d5ceffe3a4deda0054cba969835a2

出典データセット

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08455638B2