Methyl iodide → 1-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one O-Methyloxime

HRID 12561ノート

反応式

HRID 12561 の反応式
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]([C:19](=[N:22][OH:23])[CH2:20][CH3:21])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[CH3:26]I>C1COCC1>[CH3:26][O:23][N:22]=[C:19]([C:10]1[CH:9]=[CH:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[C:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:11]=1)[CH2:20][CH3:21]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 1363323391-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one Oxime2 回

生成物 1

HCID 722584711-(5,6-Diphenyl-pyridin-2-yl)-propan-1-one O-Methyloxime

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Following General Procedure Q, 1-(5,6-diphenyl-pyridin-2-yl)-propan-1-one oxime (Compound 81, 30 mg, 0.1 mmol), NaH (4.8 mg, 0.20 mmol) and MeI (140 mg, 0.99 mmol) in THF were reacted to obtain the title compound as an oil.

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-d523504399db40809f5e980e4e1ea47f
出典データセット
uspto-grants-2010_06
特許番号
US07728014B2

反応ノート

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