ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Methanol → 8-[1-(2,3-Dihydroxy-propyl)-cyclopropanesulfonylamino]-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-carboxylic acid tert-butyl ester

HRID 1259377
ノート
印刷プレビュー

反応式

HRID 1259377 の反応式
[C:1]([O:5][C:6]([N:8]1[C:12]2=[C:13]([NH:28][S:29](C3(CC=C)CC3)(=[O:31])=[O:30])[C:14]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([I:26])=[CH:22][C:21]=3[F:27])=[C:15]([CH3:18])[C:16](=[O:17])[N:11]2[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C[N+]1([O-])CC[O:42][CH2:41]C1.[CH3:46]O.[CH2:48]1[CH2:52][O:51][CH2:50][CH2:49]1>O.C(Cl)(Cl)Cl.O=[Os](=O)(=O)=O>[C:1]([O:5][C:6]([N:8]1[C:12]2=[C:13]([NH:28][S:29]([C:49]3([CH2:48][CH:52]([OH:51])[CH2:41][OH:42])[CH2:46][CH2:50]3)(=[O:31])=[O:30])[C:14]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([I:26])=[CH:22][C:21]=3[F:27])=[C:15]([CH3:18])[C:16](=[O:17])[N:11]2[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 82029Methyl morpholine oxideHCID 673454828-(1-Allyl-cyclopropanesulfonylamino)-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 67193830
8-[1-(2,3-Dihydroxy-propyl)-cyclopropanesulfonylamino]-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-carboxylic acid tert-butyl ester

試薬・触媒・溶媒 3

HCID 30318Osmium Tetroxide触媒HCID 962Water溶媒HCID 6212Chloroform溶媒

実験手順

OsO4 (0.004 g, 0.00002 mol) was added to a stirred solution of 8-(1-allyl-cyclopropanesulfonylamino)-7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-imidazo[1,2-a]pyridine-1-carboxylic acid tert-butyl ester (125 mg, 0.0002 mol) and N-methylmorpholine-N-oxide (34 mg, 0.0003 mol) in water and THF (3 mL). The resulting mixture was stirred at room temperature for 3 hours. The reaction was monitored by TLC (10% MeOH in CHCl3). The reaction mixture was partitioned between ethylacetate and water. The organic layer concentrated to afford 80 mg of the crude product which was used in the next step without further purification.

後処理

  1. customThe reaction mixture was partitioned between ethylacetate and water
  2. concentrationThe organic layer concentrated

出典と根拠

ORDレコード
ord-75cc4fdf6d7f44ca98abb531cfeca682
出典データセット
uspto-grants-2013_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08466289B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート