Formaldehyde → N-[(1-benzyl-1H-pyrrol-2-yl)methyl]-N,N-dimethylamine

HRID 1282351

反応式

HRID 1282351 の反応式
Cl.[CH3:2][NH:3][CH3:4].[CH2:5]=O.[CH2:7]([N:14]1[CH:18]=[CH:17][CH:16]=[CH:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>>[CH3:2][N:3]([CH2:5][C:15]1[N:14]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:18]=[CH:17][CH:16]=1)[CH3:4]

参加物

5

反応物 4

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 14798Sodium HydroxideHCID 749221H-Pyrrole, 1-(phenylmethyl)-

生成物 1

HCID 818704N-[(1-benzyl-1H-pyrrol-2-yl)methyl]-N,N-dimethylamine

実験手順

A solution of 8.2 g. (0.1 mole) dimethylamine hydrochloride in 8 ml. formalin is added dropwise to 17.12 g. (0.1 mole) of 1-benzylpyrrole. The mixture is stirred at room temperature until solution occurs (about 4 hours). The solution is poured into 10% sodium hydroxide solution and then extracted into ether three times. The combined organic fractions are washed with a saturated solution of sodium chloride, dried over magnesium sulfate and the solvent evaporated in vacuo. The product, 2-dimethylaminomethyl-1-benzylpyrrole, is distilled at reduced pressure, b.p. 73° C., 0.025 mm. Hg.

後処理

  1. custom(about 4 hours)
  2. extractionextracted into ether three times
  3. washThe combined organic fractions are washed with a saturated solution of sodium chloride
  4. dry with materialdried over magnesium sulfate
  5. customthe solvent evaporated in vacuo
  6. distillationThe product, 2-dimethylaminomethyl-1-benzylpyrrole, is distilled at reduced pressure, b.p. 73° C., 0.025 mm. Hg

出典と根拠

ORDレコード
ord-9ed59086687e4977b52842e0a994e516
出典データセット
uspto-grants-2002_09
特許番号
US06455703B2

関連ノート

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