Trifluoroacetic acid → 2-Pyrrolidineheptanoic acid

HRID 1283848

反応式

HRID 1283848 の反応式
C(OC([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10](O)=O)=O)(C)(C)C.Cl[CH2:17][CH2:18][CH2:19][CH2:20]CCC.F[C:25](F)(F)[C:26]([OH:28])=[O:27]>[Pd]>[NH:8]1[CH2:15][CH2:14][CH2:13][CH:9]1[CH2:10][CH2:17][CH2:18][CH2:19][CH2:20][CH2:25][C:26]([OH:28])=[O:27]

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 123711-ChloroheptaneHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

生成物 1

HCID 215167142-Pyrrolidineheptanoic acid

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

2-Pyrrolidineheptanoic acid is prepared from N-t-butoxycarbonylproline following steps A and B of Example 4 and step C of the procedure of Example 15. In step C, benzyl ω -chlorohexanoate is substituted for the 1-chloroheptane. The product thus obtained is hydrogenated in the presence of 10% palladium on charcoal and is then treated with trifluoroacetic acid, as in step E of the same procedure.

後処理

  1. customThe product thus obtained

出典と根拠

ORDレコード
ord-ac43cdb103e74c488b72722a12b4803a
出典データセット
uspto-grants-1976_08
特許番号
US03976660

関連ノート

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