Trifluoroacetic acid → 2-Pyrrolidineheptanoic acid
反応式
C(OC([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10](O)=O)=O)(C)(C)C.Cl[CH2:17][CH2:18][CH2:19][CH2:20]CCC.F[C:25](F)(F)[C:26]([OH:28])=[O:27]>[Pd]>[NH:8]1[CH2:15][CH2:14][CH2:13][CH:9]1[CH2:10][CH2:17][CH2:18][CH2:19][CH2:20][CH2:25][C:26]([OH:28])=[O:27]参加物
5
実験手順
2-Pyrrolidineheptanoic acid is prepared from N-t-butoxycarbonylproline following steps A and B of Example 4 and step C of the procedure of Example 15. In step C, benzyl ω -chlorohexanoate is substituted for the 1-chloroheptane. The product thus obtained is hydrogenated in the presence of 10% palladium on charcoal and is then treated with trifluoroacetic acid, as in step E of the same procedure.
後処理
- customThe product thus obtained
出典と根拠
- ORDレコード
- ord-ac43cdb103e74c488b72722a12b4803a
- 出典データセット
- uspto-grants-1976_08
- 特許番号
- US03976660
反応ノート
読み込み中…