Sodium hydride → 4-(2,4-dichlorophenyl)-5-methyl-2-[N-(alpha-methylbenzyl)-N-(cyclopropylmethyl)amino]thiazole

HRID 128694ノート

反応式

HRID 128694 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([NH:15][CH:16]([CH3:23])[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[S:12][C:13]=1[CH3:14].BrC(C)C([C:28]1[CH:33]=[CH:32][C:31](Cl)=CC=1Cl)=O.[H-].[Na+]>O1CCCC1.C1(CBr)CC1.C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]([N:15]([CH:16]([CH3:23])[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:31][CH:32]2[CH2:28][CH2:33]2)[S:12][C:13]=1[CH3:14]

参加物

7

反応物 3

HCID 24758Sodium hydrideHCID 109239912-Bromo-1-(2,4-dichlorophenyl)propan-1-oneHCID 193748634-(2,4-dichlorophenyl)-5-methyl-2-[N-(alpha-methylbenzyl)amino]thiazole

生成物 1

HCID 193748504-(2,4-dichlorophenyl)-5-methyl-2-[N-(alpha-methylbenzyl)-N-(cyclopropylmethyl)amino]thiazole

試薬・触媒・溶媒 3

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒HCID 81503Bromomethylcyclopropane溶媒

実験手順

At 0° C., add 0.5 g of 4-(2,4-dichlorophenyl)-5-methyl-2-[N-(α-methylbenzyl)amino]thiazole (prepared from Compound 92 and Compound 15 according to the process described in Example 1), dissolved in 5 ml of anhydrous tetrahydrofuran, and 66 mg of sodium hydride. After 30 minutes of stirring at room temperature, run in 0.67 ml of cyclopropylmethyl bromide dropwise. Leave for eight hours under reflux, cool and dilute the reaction medium with methylene chloride, then pour it onto ice.

後処理

  1. customLeave for eight hours
  2. temperatureunder reflux
  3. temperaturecool
  4. additionpour it onto ice

出典と根拠

ORDレコード
ord-3582406116dd456cb4435c34ea56e06e
出典データセット
uspto-grants-1995_11
特許番号
US05464847

反応ノート

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