Tetrahydrofuran → 5-Amino-3-(4-chloro-1-naphthyl)-1-[methylamino(thiocarbonyl)]-1H-1,2,4-triazole

HRID 1289772ノート

反応式

HRID 1289772 の反応式
[NH2:1][C:2]1[N:6]=[C:5]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([Cl:17])=[CH:9][CH:8]=2)[NH:4][N:3]=1.[OH-].[Na+].[CH3:20][N:21]=[C:22]=[S:23].O1CCCC1>C(Cl)(Cl)Cl>[NH2:1][C:2]1[N:3]([C:22]([NH:21][CH3:20])=[S:23])[N:4]=[C:5]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([Cl:17])=[CH:9][CH:8]=2)[N:6]=1

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 11167Methyl isothiocyanateHCID 14798Sodium HydroxideHCID 107528543-Amino-5-(4-chloro-1-naphthyl)-1H-1,2,4-triazol

生成物 1

HCID 105916075-Amino-3-(4-chloro-1-naphthyl)-1-[methylamino(thiocarbonyl)]-1H-1,2,4-triazole収率 5%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

The synthesis method of Example 7-(3) was applied. The compound (2.19 g) obtained in (4) above, a 1N sodium hydroxide solution (10.0 ml), methyl isothiocyanate (1.38 g) and tetrahydrofuran (10 ml) were used as reagents. After the reaction, silica gel column chromatography (chloroform) and recrystallization from chloroform gave 135 mg of white crystals (yield 5% from methyl 4-chloro-1-naphthoate).

出典と根拠

ORDレコード
ord-2974aa6beeca4219865fcf73d63b5b3e
出典データセット
uspto-grants-1998_05
特許番号
US05750545

反応ノート

読み込み中…