4-Bromobiphenyl → 4-BROMO-4'-SULFOBIPHENYL

HRID 1292243ノート

反応式

HRID 1292243 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 71014-BromobiphenylHCID 24638Chlorosulfonic acid

生成物 1

HCID 45247074-BROMO-4'-SULFOBIPHENYL収率 79.5%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a stirred solution of 4-bromobiphenyl (50 g, 0.21 mol) in chloroform (200 mL) was added dropwise at room temperature chlorosulfonic acid (32.5 g, 0.28 mol). The solution was stirred at room temperature for 16 hours, then diluted with hexanes (200 mL). The precipitate was collected by filtration and washed with hexanes to give 4'-bromobiphenyl-4-sulfonic acid (52.3 g, 79%) as a white solid. The crude product was used in the next step without further characterization.

後処理

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with hexanes

出典と根拠

ORDレコード
ord-a769a92bc2f64a84af08b23594258d81
出典データセット
uspto-grants-1998_05
特許番号
US05756545

反応ノート

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