Acetic Anhydride → N-(hydroxymethyl)acetamide acetate

HRID 129623

反応式

HRID 129623 の反応式
[C:1]([O:4]C(=O)C)(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]>N1C=CC=CC=1>[C:1]([OH:4])(=[O:3])[CH3:2].[OH:8][CH2:9][NH:10][C:11](=[O:13])[CH3:12]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 69365Formicin

生成物 1

HCID 86745977N-(hydroxymethyl)acetamide acetate収率 900%

試薬・触媒・溶媒 1

HCID 1049Pyridine触媒

実験手順

Acetic anhydride (25 g) and pyridine (10 drops) is added to N-(hydroxymethyl)acetamide (9 g, 0.1 mol). The reaction mixture is stirred overnight at room temperature, concentrated in vacuo and chased with xylene to give the title product as an oil (11.9 g, 0.9 mol) which is identified by 1HNMR spectral analysis.

後処理

  1. concentrationconcentrated in vacuo and chased with xylene

出典と根拠

ORDレコード
ord-7c0bd3edec95447594664c9e2887776d
出典データセット
uspto-grants-1995_11
特許番号
US05468877

関連ノート

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