Pyridine → HCID 23125865、化合物

HRID 132732

反応式

HRID 132732 の反応式
[C:1]1([C:9]2[C:10]([CH2:15][OH:16])=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:2]([CH2:7][OH:8])=[CH:3][CH:4]=[CH:5][CH:6]=1.N1C=C[CH:20]=[CH:19][CH:18]=1.[C:23](Cl)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[O:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1>>[C:23]([O:16][CH2:15][C:10]1[C:9]([C:1]2[C:2]([CH2:7][O:8][C:36](=[O:32])[C:35]3[CH:20]=[CH:19][CH:18]=[CH:33][CH:34]=3)=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

参加物

5

反応物 4

HCID 1049PyridineHCID 7412Benzoyl chlorideHCID 8028TetrahydrofuranHCID 243265(1,1'-Biphenyl)-2,2'-dimethanol

生成物 1

HCID 23125865HCID 23125865、化合物収率 93%

実験手順

To 0.03 mol 2,2′-biphenyldimethanol was added 30 ml tetrahydrofuran and 0.09 mol pyridine, then added 0.075 mol benzoyl chloride with stirring. The reaction mixture was heated refluxing for 4 hours, cooled and added 20 ml saturated saline. The mixture was extracted with ethyl acetate, and extract was dried over anhydrous sodium sulfate. The solvent was removed. Column chromatography gave 2,2′-biphenyldimethanol dibenzoate as a colorless viscous liquid, and the yield was 93%.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperaturerefluxing for 4 hours
  3. temperaturecooled
  4. additionadded 20 ml saturated saline
  5. extractionThe mixture was extracted with ethyl acetate
  6. extractionextract
  7. dry with materialwas dried over anhydrous sodium sulfate
  8. customThe solvent was removed

出典と根拠

ORDレコード
ord-95eff78e70df4997a65f9cd5b2102bbd
出典データセット
uspto-grants-2008_06
特許番号
US07388061B2

関連ノート

読み込み中…