Hydrogen Peroxide → 1-Cyclohexyloxy-2,2,6,6-tetramethyl-piperidin-4-ol

HRID 133650

反応式

HRID 133650 の反応式
[CH3:1][C:2]1([CH3:11])[CH2:7][CH:6]([OH:8])[CH2:5][C:4]([CH3:10])([CH3:9])[NH:3]1.[C:12](=[O:15])([O-])[O-].[Na+].[Na+].OO.F[B-](F)(F)F.[H+].S([O-])([O-])=O.[Na+].[Na+]>O.C(#N)C.C1CCCCC1>[CH:12]1([O:15][N:3]2[C:4]([CH3:10])([CH3:9])[CH2:5][CH:6]([OH:8])[CH2:7][C:2]2([CH3:11])[CH3:1])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:9]1

参加物

9

反応物 5

HCID 784Hydrogen PeroxideHCID 10340Sodium CarbonateHCID 24437Sodium SulfiteHCID 28118Tetrafluoroboric acidHCID 754714-Hydroxy-2,2,6,6-tetramethylpiperidine

生成物 1

HCID 113228111-Cyclohexyloxy-2,2,6,6-tetramethyl-piperidin-4-ol

試薬・触媒・溶媒 3

HCID 962Water溶媒2 回HCID 6342Acetonitrile溶媒2 回HCID 8078Cyclohexane溶媒

反応条件

温度
56 °C

実験手順

A mixture of 5.21 g (33.1 mmol) of 2,2,6,6-tetramethylpiperidin-4-ol, 0.015 g (0.142 mmol) of anhydrous sodium carbonate, 15 ml of water, and 15 ml of acetonitrile is heated to 56° C. A solution of 6.5 g (96 mmol) of 50% aqueous hydrogen peroxide is added to the reaction mixture over 1.5 hours while the temperature is brought to and maintained at 80° C. After the peroxide is added, the reaction mixture is heated at 80° C. for 3 hours, then cooled slowly to 50° C. over 1.75 hours. The mixture is kept at ambient temperature overnight. A solution of 0.184 g (0.662 mmol) of ferrous sulfate heptahydrate and 0.664 g (3.6 mmol) of 48% tetrafluoroboric acid in 2 ml of water is added to the reaction mixture, followed by 30 ml of cyclohexane and 24 ml of acetonitrile. The reaction mixture is heated to 50° C. A solution of 8.7 g (128 mmol) of 50% aqueous peroxide is added to the reaction mixture dropwise over 4.5 hours while the temperature is brought to and maintained at 62° C. After the peroxide is added, the reaction mixture is stirred at reflux for 1 hour. Upon cooling, residual peroxide is decomposed by the addition of aqueous sodium sulfite solution. Work-up with ethyl acetate and purification by flash chromatography afford 2.03 g (24% overall yield) of a white solid. GC analysis shows that the reaction product has a retention time identical to that of an authentic sample of the title compound.

後処理

  1. temperaturemaintained at 80° C
  2. temperaturethe reaction mixture is heated at 80° C. for 3 hours
  3. temperaturecooled slowly to 50° C. over 1.75 hours
  4. temperatureThe reaction mixture is heated to 50° C
  5. temperaturemaintained at 62° C
  6. temperatureat reflux for 1 hour
  7. temperatureUpon cooling
  8. customWork-up with ethyl acetate and purification by flash chromatography
  9. customafford
  10. custom2.03 g (24% overall yield) of a white solid

出典と根拠

ORDレコード
ord-51931e27059f49838a83bc55297eb17b
出典データセット
uspto-grants-2008_06
特許番号
US07390904B2

関連ノート

読み込み中…