p-Fluorophenethylamine → HCID 21098561、化合物

HRID 1351256ノート

反応式

HRID 1351256 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[CH:11]([N:14](CC)C(C)C)(C)[CH3:12].BrCC#N>C(#N)C.C(OCC)(=O)C>[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH:8][CH2:12][C:11]#[N:14])=[CH:4][CH:3]=1

参加物

6

反応物 3

HCID 4653p-FluorophenethylamineHCID 11534BromoacetonitrileHCID 81531Diisopropylethylamine

生成物 1

HCID 21098561HCID 21098561、化合物

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 4-fluorophenethylamine (1.4 g) in acetonitrile (20 mL) was added dropwise N,N-diisopropylethylamine (2.6 mL) and bromoacetonitrile (0.84 mL). After stirring at room temperature for 50 minutes, the solution was diluted with ethyl acetate, the solution was washed with water, then with saturated sodium chloride water. After drying with anhydrous sodium sulfate, the solvent was removed by evaporation to provide the title compound (2.12 g) as a yellow oily substance.

後処理

  1. washthe solution was washed with water
  2. dry with materialAfter drying with anhydrous sodium sulfate
  3. customthe solvent was removed by evaporation

出典と根拠

ORDレコード
ord-4a0da7085a9d4a9db625dd90774ae72a
出典データセット
uspto-grants-2007_05
特許番号
US07217723B2

反応ノート

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