Diethylene Glycol → 2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanol

HRID 1358880

反応式

HRID 1358880 の反応式
[CH2:1]([OH:7])[CH2:2][O:3][CH2:4][CH2:5][OH:6].[H-].[Na+].[Cl-].[CH3:11][SiH:12]([CH3:17])[C:13]([CH3:16])([CH3:15])[CH3:14]>O1CCCC1>[CH3:14][C:13]([Si:12]([CH3:17])([CH3:11])[O:7][CH2:1][CH2:2][O:3][CH2:4][CH2:5][OH:6])([CH3:16])[CH3:15]

参加物

5

反応物 3

HCID 8117Diethylene GlycolHCID 24758Sodium hydrideHCID 131722836Tert-butyldimethylsilane chloride

生成物 1

HCID 111175822-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanol収率 97.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

20 g of diethyleneglycol is added to 9.05 g of sodium hydride in 320 cm3 of tetrahydrofuran, the reaction medium is agitated for 45 minutes, 28.3 g of dimethylterbutylsilane chloride is added, agitation is carried out for 3 hours while leaving the temperature to return to ambient. Extraction is carried out with ether, followed by washing with an aqueous solution of sodium bicarbonate, with salt water, drying and evaporating the solvent. 40.25 g of expected product is obtained.

後処理

  1. waitagitation is carried out for 3 hours
  2. customwhile leaving the temperature
  3. extractionExtraction
  4. washby washing with an aqueous solution of sodium bicarbonate, with salt water
  5. customdrying
  6. customevaporating the solvent

出典と根拠

ORDレコード
ord-90299c7a679946a99270dd0793685b67
出典データセット
uspto-grants-2003_07
特許番号
US06596885B2

関連ノート

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