Salicyl Alcohol → [2-(2-Morpholinoethoxy)phenyl]methanol

HRID 1359664

反応式

HRID 1359664 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].Cl.Cl[CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>[OH-].[Na+]>[N:14]1([CH2:13][CH2:12][O:1][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH2:4][OH:5])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

参加物

4

反応物 2

HCID 5146Salicyl AlcoholHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

生成物 1

HCID 7164615[2-(2-Morpholinoethoxy)phenyl]methanol

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A mixture of 2-hydroxybenzyl alcohol (1.295 g, 10.4 mmol) and 4-(2-chloroethyl)morpholine hydrochloride (1.94 g, 10.4 mmol) in 2N NaOH (10.5 mL) was stirred at rt for 14 hours. The precipitate was collected by vacuum filtration, washed with 1N NaOH, redissolved in DCM and washed with 1N NaOH. The aqueous layer was extracted with more DCM (2×). The combined DCM was dried and concentrated to give [2-(2-morpholin-4-yl-ethoxy)-phenyl]-methanol which was used without further purification.

後処理

  1. filtrationThe precipitate was collected by vacuum filtration
  2. washwashed with 1N NaOH
  3. dissolutionredissolved in DCM
  4. washwashed with 1N NaOH
  5. extractionThe aqueous layer was extracted with more DCM (2×)
  6. dry with materialThe combined DCM was dried
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-7b584bb1f44649918b9acb5561442590
出典データセット
uspto-grants-2003_07
特許番号
US06599902B2

関連ノート

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