7-Nitroindole → 7-Aminoindole

HRID 13692

反応式

HRID 13692 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][CH:10]=[CH:9]2)([O-])=O.C([O-])=O.[NH4+]>C(O)C.[Pd]>[NH:11]1[C:12]2[C:8](=[CH:7][CH:6]=[CH:5][C:4]=2[NH2:1])[CH:9]=[CH:10]1

参加物

5

反応物 2

HCID 233967-NitroindoleHCID 2723923Ammonium formate

生成物 1

HCID 1116347-Aminoindole収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Dissolve 7-nitroindole in ethanol and add ammonium formate (10 equivalents) and a catalytic amount of 10% palladium on carbon. Heat the mixture to reflux for 1 hr before cooling, filter through celite, and evaporate to provide the product as a purple solid (99%).

後処理

  1. temperatureHeat the mixture
  2. temperatureto reflux for 1 hr
  3. temperaturebefore cooling
  4. filtrationfilter through celite
  5. customevaporate

出典と根拠

ORDレコード
ord-d66e2b89479b4a10883eee173cc6ba93
出典データセット
uspto-grants-2010_06
特許番号
US07728150B2

関連ノート

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