Benzyl Alcohol → Di-tert-butyl ether

反応式

[CH2:1](O)[C:2]1[CH:7]=CC=C[CH:3]=1.[CH3:9][C:10](=[CH2:12])[CH3:11].C(NC(=[O:23])C(Cl)(Cl)Cl)(C)(C)C.B(F)(F)F.CCOCC>ClCCl.P(=O)(O)(O)O.B(F)(F)F.CCOCC.C1CCCCC1.C1CCCCC1.ClCCl.C(Cl)(Cl)Cl>[C:10]([O:23][C:2]([CH3:1])([CH3:3])[CH3:7])([CH3:11])([CH3:9])[CH3:12]

参加物

実験手順

Benzyl alcohol derivatives E6 dissolved in dichloromethane or chloroform are treated with isobutylene in phosphoric acid-boron trifluoride etherate for about 1 to 3 hours at about -78° C. to -60° C. then 18 hours at room temperature or with tert-butyl-2,2,2-trichloroacetamidate in the presence of a catalytic amount of boron trifluoride etherate in cyclohexane or in a mixture of cyclohexane-dichloromethane at room temperature for about 18-24 hours to produce tert-butyl ether derivatives E7.