Acetone Cyanohydrin → HCID 178463102、化合物

HRID 1385031

反応式

HRID 1385031 の反応式
[Br:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([C:12]([OH:14])=O)=[CH:4][CH:3]=1.[CH2:15]([N:17]1[C:21]([OH:22])=[CH:20][CH:19]=[N:18]1)[CH3:16].C1(N=C=NC2CCCCC2)CCCCC1.CC(C)(O)C#N.C(=O)([O-])[O-].[Na+].[Na+]>C(#N)C.C(N(CC)CC)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([C:20]2[CH:19]=[N:18][N:17]([CH2:15][CH3:16])[C:21]=2[OH:22])=[O:14])=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2

参加物

8

反応物 5

HCID 6406Acetone CyanohydrinHCID 10340Sodium CarbonateHCID 10868DicyclohexylcarbodiimideHCID 110213638-bromoquinoline-5-carboxylic AcidHCID 178418331HCID 178418331、化合物

生成物 1

HCID 178463102HCID 178463102、化合物

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 8471Triethylamine溶媒

実験手順

1.00 g of 8-bromoquinoline-5-carboxylic acid, 0.44 g of 1-ethyl-5-hydroxypyrazole and 0.80 g of dicyclohexylcarbodiimide were stirred in 15 ml of acetonitrile at room temperature. After the addition of 0.2 ml of acetone cyanohydrin and 0.60 g of triethylamine, stirring was continued for 1.5 hours and the mixture was then poured into aqueous sodium carbonate solution. The alkaline phase was washed with ethyl acetate and diethyl ether and then acidified. The precipitate was filtered off under suction and the aqueous phase was extracted with ethyl acetate. This organic phase was dried and concentrated. The residue and the precipitate were combined.

後処理

  1. washThe alkaline phase was washed with ethyl acetate and diethyl ether
  2. filtrationThe precipitate was filtered off under suction
  3. extractionthe aqueous phase was extracted with ethyl acetate
  4. customThis organic phase was dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-9fdd006d23c84e68816f4a08d800cf40
出典データセット
uspto-grants-2001_07
特許番号
US06262074B1

関連ノート

読み込み中…