Ethyl bromoacetate → Glycine, N-(4-chlorophenyl)-, ethyl ester

HRID 1392758

反応式

HRID 1392758 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7748Ethyl bromoacetateHCID 78124-ChloroanilineHCID 11430Potassium Carbonate

生成物 1

HCID 302644Glycine, N-(4-chlorophenyl)-, ethyl ester収率 85.6%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

4-Chloroaniline (2.0 g) was dissolved in acetonitrile (20 ml), and ethyl bromoacetate (2.1 g) and potassium carbonate (2.2 g) were added to stir the mixture at 60° C. for 2 days. The reaction mixture was filtered through Celite pad, and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1) to obtain the title compound (2.3 g).

後処理

  1. filtrationThe reaction mixture was filtered through Celite pad
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1)

出典と根拠

ORDレコード
ord-ddfb4b074a4041119d5d2fc3840b3ecd
出典データセット
uspto-grants-2008_03
特許番号
US07342014B2

関連ノート

読み込み中…