Ethyl chloroacetate → Glycine, N-(4-chlorophenyl)-, ethyl ester

HRID 1402830

反応式

HRID 1402830 の反応式
O.O.O.C([O-])(=O)C.[Na+].Cl[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1>C(O)C>[Cl:16][C:17]1[CH:23]=[CH:22][C:20]([NH:21][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 7751Ethyl chloroacetateHCID 78124-ChloroanilineHCID 23665404Sodium Acetate Trihydrate

生成物 1

HCID 302644Glycine, N-(4-chlorophenyl)-, ethyl ester収率 55.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium acetate trihydrate (6 g) was added to a solution of commercial ethyl chloroacetate (6.2 g) and commercial 4-chloroaniline (6.4 g) in ethanol (5 ml). The mixture was heated to reflux for 5 h. After cooling in an ice bath the product precipitates. The solid was collected by suction filtration and washed with water. The still wet product was recrystallised from ethanol to give ethyl N-(4-chlorophenyl)glycinate (5.99 g) as greyish crystals.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 5 h
  3. temperatureAfter cooling in an ice bath the product
  4. customprecipitates
  5. filtrationThe solid was collected by suction filtration
  6. washwashed with water
  7. customThe still wet product was recrystallised from ethanol

出典と根拠

ORDレコード
ord-f4611cbfb3fb4deea75c22e6bec2aa55
出典データセット
uspto-grants-2014_12
特許番号
US08912186B2

関連ノート

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