Hydrochloric Acid → HCID 21482850、化合物

HRID 1415559ノート

反応式

HRID 1415559 の反応式
[CH:1]1([N:7]2[CH2:11][CH2:10][CH:9](O)[CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.S(Cl)([Cl:16])=O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH:1]1([N:7]2[CH2:11][CH2:10][CH:9]([Cl:16])[CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 24386Thionyl ChlorideHCID 133874481-Cyclohexylpyrrolidin-3-ol

生成物 1

HCID 21482850HCID 21482850、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a stirred solution of 169 g. of N-cyclohexyl-3-pyrrolidinol in 600 ml. of chloroform, acidified with gaseous hydrogen chloride, is added 130 g. of thionyl chloride. This solution is refluxed for four hours, then poured onto ice water and made basic with sodium carbonate. The organic layer is dried over sodium sulfate, concentrated, and the residue distilled in vacuo to give N-cyclohexyl-3-chloropyrrolidine.

後処理

  1. additionis added 130 g
  2. temperatureThis solution is refluxed for four hours
  3. additionpoured onto ice water
  4. dry with materialThe organic layer is dried over sodium sulfate
  5. concentrationconcentrated
  6. distillationthe residue distilled in vacuo

出典と根拠

ORDレコード
ord-e93ea8fede624f6e8a34b414d514bad6
出典データセット
uspto-grants-1977_01
特許番号
US04005208

反応ノート

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