Trifluoroacetic acid → (S)-Ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

HRID 1429410ノート

反応式

HRID 1429410 の反応式
[C:1](/[CH:3]=[CH:4]/[C@H:5]([N:13]([CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][C:24]([F:27])([F:26])[F:25])(=[O:16])=[O:15])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)#[N:2].C(O)(C(F)(F)F)=O>CO.O=[Pt]=O.[Pt]>[NH2:2][CH2:1][CH2:3][CH2:4][C@H:5]([N:13]([CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][C:24]([F:26])([F:27])[F:25])(=[O:16])=[O:15])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

6

反応物 2

HCID 6422Trifluoroacetic acidHCID 71277869(R,E)-Ethyl 2-(N-(4-cyano-1-phenylbut-3-en-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

生成物 1

HCID 71277454(S)-Ethyl 2-(N-(5-amino-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

試薬・触媒・溶媒 3

HCID 23939Platinum触媒HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

To a solution of compound 31h (3.7 g, 7.7 mmol) in MeOH (200 mL) were added PtO2 (0.1 g), Pt/C (0.3 g) and TFA (1.9 g). The mixture was hydrogenated in a Parr shaker at 48 psi for 12 h. The mixture was filtered and concentrated. The product was directly used in the next reaction step without further purification.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated
  3. customThe product was directly used in the next reaction step without further purification

出典と根拠

ORDレコード
ord-9ef68e43c63946d689288ba4f52207e5
出典データセット
uspto-grants-2015_01
特許番号
US08940722B2

反応ノート

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