Dimethylformamide → 2(3H)-Benzofuranone, 3,3-dimethyl-

HRID 1453038

反応式

HRID 1453038 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][C:2]1=O.[H-].[Na+].[CH3:13]I.CN([CH:18]=[O:19])C>C1COCC1>[CH3:2][C:3]1([CH3:13])[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[O:1][C:18]1=[O:19]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 6328Methyl iodide2 回HCID 24758Sodium hydrideHCID 683822(3H)-Benzofuranone

生成物 1

HCID 5956202(3H)-Benzofuranone, 3,3-dimethyl-収率 65%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 3H-Benzofuran-2-one (4.02 g, 30 mmol) dissolved in THF (15 mL) was added cautiously to a suspension of NaH (95% dry, 1.58 g, 66 mmol) in DMF (60 mL) and THF (30 mL) under a nitrogen atmosphere, at 0° C. The mixture was stirred until gas evolution ceased, then MeI (5.6 mL, 90 mmol) was added slowly to avoid boiling over. After MeI addition was complete the reaction further stirred 1 h at room temperature then quenched by carefully pouring onto a mixture of HCl (1N) and ice. The resulting solution was extracted with ether, washed with brine, dried over MgSO4, and chromatographed on silica eluted with a gradient of 5-50% ethyl acetate/hexanes, yielding 3.16 g (65% yield) of the product.

後処理

  1. stirringfurther stirred 1 h at room temperature
  2. customthen quenched
  3. additionby carefully pouring onto a mixture of HCl (1N) and ice
  4. extractionThe resulting solution was extracted with ether
  5. washwashed with brine
  6. dry with materialdried over MgSO4
  7. customchromatographed on silica
  8. washeluted with a gradient of 5-50% ethyl acetate/hexanes

出典と根拠

ORDレコード
ord-95196d6618b24c699cd9df003bb44421
出典データセット
uspto-grants-2009_01
特許番号
US07473790B2

関連ノート

読み込み中…