Methyl iodide → HCID 69849154、化合物

反応式

[C:1]12([N:11]3[C:15](=[O:16])[C:14]([CH2:23][C:24]4[CH:28]=[CH:27][O:26][CH:25]=4)([CH2:17][C:18]4[CH:22]=[CH:21][O:20][CH:19]=4)[NH:13][C:12]3=[O:29])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[H-].[Na+].[CH3:32]I>C1COCC1>[C:1]12([N:11]3[C:15](=[O:16])[C:14]([CH2:23][C:24]4[CH:28]=[CH:27][O:26][CH:25]=4)([CH2:17][C:18]4[CH:22]=[CH:21][O:20][CH:19]=4)[N:13]([CH3:32])[C:12]3=[O:29])[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:9]3)[CH2:8]1)[CH2:10]2

参加物

実験手順

Under a N2 atmosphere was combined 3-adamantan-1-yl 5,5-bis-furan-3-ylmethyl-imidazolidine-2,4-dione (0.100 g, 0.25 mmol) in 2 ml of dry THF. To this solution was added a 60% dispersion of sodium hydride (11.1 mg, 0.28 mmol) and the suspension was allowed to stir for 1.5 hours. To this reaction mixture was then added methyl iodide (32 μl, 0.508 mmol) and the reaction mixture was allowed to stir for 30 minutes and quenched with water and extracted with 2×30 ml of methylene chloride (CH2Cl2). The organic layer was separated, dried over MgSO4, filtered and concentrated in vacuo to yield 0.103 g of the title compound.