Pyridine → HCID 15019923、化合物

HRID 1460416ノート

反応式

HRID 1460416 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.N1C=CC=CC=1.[N+](C1C=CC=CC=1)([O-])=O.[C:33](Cl)(=[O:36])[CH:34]=[CH2:35]>O.O1CCCC1>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([C:11]2[CH:17]=[CH:16][C:14]([NH:15][C:33](=[O:36])[CH:34]=[CH2:35])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

参加物

7

反応物 4

HCID 1049PyridineHCID 7416NitrobenzeneHCID 13140Acryloyl chlorideHCID 1176864-((4-Aminophenyl)sulfonyl)phenol

生成物 1

HCID 15019923HCID 15019923、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 4-(4'-hydroxyphenylsulfonyl)aniline (23.3 g), pyridine (9.4 g) and nitrobenzene (1 ml) is added to 400 ml of tetrahydrofuran. To the ice-cooled solution, 9.0 g of acrylic acid chloride is added dropwise and stirred for 30 min. The stirred mixture is added to 2,000 ml of water and the precipitating crystal is separated by filtration. The resulting crystal is recrystallized with ethanol to obtain the end compound in an amount of 28.5 g. The structure of this compound is verified by IR, NMR and mass spectra.

後処理

  1. additionis added dropwise
  2. customthe precipitating crystal is separated by filtration
  3. customThe resulting crystal is recrystallized with ethanol
  4. customto obtain the end compound in an amount of 28.5 g

出典と根拠

ORDレコード
ord-342b39efb741490ab8fb551f708e8e4e
出典データセット
uspto-grants-1991_12
特許番号
US05071738

反応ノート

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