Formaldehyde → 3,5-Dichlorosalicyl alcohol
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[OH:9].[OH-:10].[Na+].[CH2:12]=O>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:3]([OH:9])=[C:4]([CH:5]=[C:6]([Cl:8])[CH:7]=1)[CH2:12][OH:10]参加物
5
実験手順
A mixture of 2,4-dichlorophenol (15.3 g), 10% sodium hydroxide solution (100 ml) and 40% aqueous formaldehyde solution (37.5 ml) was heated at 95°-100° C. for 4 hr, then cooled and acidified by addition of 2-normal sulphuric acid (70 ml). The precipitated oil was extracted into toluene, and the extract washed with sodium bicarbonate solution, dried and evaporated. The residue was recrystallised from boiling water to yield 3,5-dichloro-2-hydroxybenzyl alcohol (4.0 g), m.p. 81°-82° C. on drying at 56° C./20 mm. Hg=2660 Pa.
後処理
- temperaturewas heated at 95°-100° C. for 4 hr
- temperaturecooled
- extractionThe precipitated oil was extracted into toluene
- washthe extract washed with sodium bicarbonate solution
- customdried
- customevaporated
- customThe residue was recrystallised
出典と根拠
- ORDレコード
- ord-3ada45b6e1414c3daf08adc4c2c5dc3f
- 出典データセット
- uspto-grants-1984_07
- 特許番号
- US04461907
反応ノート
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