1-Propanol → 2-Propoxythiophene

HRID 1464126ノート

反応式

HRID 1464126 の反応式
I[C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[Na].[CH2:8]([OH:11])[CH2:9][CH3:10]>>[CH2:8]([O:11][C:2]1[S:3][CH:4]=[CH:5][CH:6]=1)[CH2:9][CH3:10]

参加物

4

反応物 3

HCID 10311-PropanolHCID 189212-IodothiopheneHCID 5360545Sodium

生成物 1

HCID 190893322-Propoxythiophene収率 13.5%

実験手順

Iodothiophene (59 g, 281 mmole) and cupric oxide (11.2 g, 141 mmole) were placed in propanol (420 g) containing sodium (19.7 g, 857 mmole). The mixture was stirred at reflux for 48 hours and then filtered. The filtrate was added to cold water and the water extracted with ethyl ether. The ether layers were combined, dried over magnesium sulfate, filtered, concentrated, and then vacuum distilled from over sodium at 50° C. and 10 torr to provide 5.4 g of product.

後処理

  1. temperatureat reflux for 48 hours
  2. filtrationfiltered
  3. additionThe filtrate was added to cold water
  4. extractionthe water extracted with ethyl ether
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated
  8. distillationvacuum distilled from over sodium at 50° C.

出典と根拠

ORDレコード
ord-2a2513057be045588a9e1994a95d9d47
出典データセット
uspto-grants-1994_04
特許番号
US05302724

反応ノート

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