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Pyridine → 3-(4-(3-Bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazin-1-yl)-5-isopropyl-1,2,4-oxadiazole

HRID 1478279
ノート
印刷プレビュー

反応式

HRID 1478279 の反応式
[Br:1][C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[CH:9][C:8]([N:11]3[CH2:16][CH2:15][N:14]([C:17]#[N:18])[CH2:13][CH2:12]3)=[N:7][C:6]=12.C(=O)([O-])[O-].[Na+].[Na+].Cl.NO.[N:28]1C=CC=CC=1.[C:34]([O:39]C(=O)C(C)C)(=O)[CH:35]([CH3:37])[CH3:36]>CN(C=O)C.C(OCC)(=O)C.C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[CH:9][C:8]([N:11]3[CH2:16][CH2:15][N:14]([C:17]4[N:28]=[C:34]([CH:35]([CH3:37])[CH3:36])[O:39][N:18]=4)[CH2:13][CH2:12]3)=[N:7][C:6]=12
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

9

反応物 5

HCID 1049PyridineHCID 7346Isobutyric anhydrideHCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 866974444-(3-Bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carbonitrile

生成物 1

HCID 866974453-(4-(3-Bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazin-1-yl)-5-isopropyl-1,2,4-oxadiazole

試薬・触媒・溶媒 3

HCID 1140Toluene溶媒HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
80 °C

実験手順

4-(3-bromopyrazolo[1,5-a]pyrimidin-5-yl)piperazine-1-carbonitrile (450 mg, 1.46 mmol) in 9 mL DMF and sodium carbonate (155 mg, 1.46 mmol) stirred room temperature 15 minutes, hydroxylamine HCl (203 mg, 2.9 mmol) added and reaction stirred 30 minutes at 80° C. Then 12 mL toluene added and pyridine (474 uL, 5.86 mmol) and isobutyricanhydride (973 uL, 5.86 mmol) added and reaction stirred at 80° C. for 1.5 hours. Reaction cooled to room temperature reduced in vacuo then taken up in ethyl acetate and washed with water, brine, water. Organic layer dried over magnesium sulfate and reduced in vacuo. For 250 mg crude product to use as is in further reactions.

後処理

  1. customreaction
  2. customreaction
  3. stirringstirred at 80° C. for 1.5 hours
  4. customReaction
  5. temperaturecooled to room temperature
  6. washwashed with water, brine, water
  7. dry with materialOrganic layer dried over magnesium sulfate

出典と根拠

ORDレコード
ord-c8ce972aadfa4426988d196459fed8ae
出典データセット
uspto-grants-2016_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09403832B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート