Methyl iodide → HCID 89580690、化合物
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[CH2:9][CH2:10][OH:11])=[CH:4][CH:3]=1.[H-].[Na+].I[CH3:16]>O1CCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH2:9][CH2:10][O:11][CH3:16])[CH3:12])=[CH:6][CH:7]=1参加物
5
実験手順
To the solution of 3-(4-bromophenyl)butan-1-ol (791 mg, 3.47 mmol) in tetrahydrofuran (50 mL) was added sodium hydride (278 mg, 6.94 mmol), the mixture was stirred at room temperature for 30 minutes, then iodomethane (985 mg, 6.94 mmol) was added, the mixture was stirred for 5 hours, then quenched with water (1 mL) concentrated and purified by column chromatography (silica gel, dichloromethane/methanol=20:1) to give 1-bromo-4-(4-methoxybutan-2-yl)benzene (541 mg, 64%).
後処理
- stirringthe mixture was stirred for 5 hours
- customquenched with water (1 mL)
- concentrationconcentrated
- custompurified by column chromatography (silica gel, dichloromethane/methanol=20:1)
出典と根拠
- ORDレコード
- ord-34a3427cab15464a9e5f4d91388e1428
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409865B2
反応ノート
読み込み中…