Diisopropylethylamine → 2-Phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one

HRID 1489031ノート

反応式

HRID 1489031 の反応式
Cl[C:2]1[N:11]2[C:12](=[O:21])[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:14]=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.C(N(CC)C(C)C)(C)C>C(O)C.C(Cl)(Cl)Cl.[Pd]>[C:15]1([N:13]2[C:12](=[O:21])[N:11]3[CH2:2][NH:3][C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=4[C:10]3=[N:14]2)[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

6

反応物 2

HCID 81531DiisopropylethylamineHCID 15428837HCID 15428837、化合物

生成物 1

HCID 1354844832-Phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 6212Chloroform溶媒

実験手順

A mixture of 5-chloro-2-phenyl-1,2,4-triazolo[4,3-c]-quinazolin-3-one (1 g, 3.4 mmol), N,N-diisopropylethylamine (1 ml, 6.7 mmol) and 10% Pd-C (200 mg) in ethanol was shaken under hydrogen at 50 psi overnight. The reaction was diluted with CHCl3 and filtered through Celite. The filtrate was evaporated under reduced pressure and the residue dissolved in dichloromethane. The solution was washed with water, dried over Na2 SO4 and evaporated under reduced pressure to yield 2-phenyl-5,6-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one (Compound 2) as a white solid. m.p. 202°-204° C.

後処理

  1. filtrationfiltered through Celite
  2. customThe filtrate was evaporated under reduced pressure
  3. dissolutionthe residue dissolved in dichloromethane
  4. washThe solution was washed with water
  5. customdried over Na2 SO4
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-781b4b12552c485a9b2e55a82612fc99
出典データセット
uspto-grants-1997_10
特許番号
US05677309

反応ノート

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