Formaldehyde → Sevoflurane

HRID 1489493

反応式

HRID 1489493 の反応式
[FH:1].[CH2:2]=O.[CH:4]([OH:13])([C:9]([F:12])([F:11])[F:10])[C:5]([F:8])([F:7])[F:6]>S(=O)(=O)(O)O>[CH2:2]([F:1])[O:13][CH:4]([C:9]([F:12])([F:11])[F:10])[C:5]([F:8])([F:7])[F:6]

参加物

5

反応物 3

HCID 712FormaldehydeHCID 135291,1,1,3,3,3-Hexafluoro-2-propanolHCID 14917Hydrofluoric Acid

生成物 1

HCID 5206Sevoflurane収率 87.5%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

反応条件

温度
65 °C

実験手順

A 500 ml reactor was charged with 50 ml of 98% sulfuric acid, 100 g (5 mol) of hydrogen fluoride, and 30 g (1 mol) of paraformaldehyde. This reaction mixture was heated to 65° C. Then, 134 g (0.8 mol) of HFIP was added dropwise, over 2 hr. Vapors generated by the reaction were collected using water. With this, 140 g of crude SEVOFLURANE was obtained.

後処理

  1. customwere collected

出典と根拠

ORDレコード
ord-c5ed7c93ae5f4696a4833a8f7e611625
出典データセット
uspto-grants-1997_10
特許番号
US05679576

関連ノート

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