Diethyl Malonate → Diethyl 2-pent-4-enylpropanedioate

HRID 1494086

反応式

HRID 1494086 の反応式
[Na].[C:2]([O:10][CH2:11][CH3:12])(=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].Br[CH2:14][CH2:15][CH2:16][CH:17]=[CH2:18]>C(O)C>[CH2:18]([CH:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:2]([O:10][CH2:11][CH3:12])=[O:9])[CH2:17][CH2:16][CH:15]=[CH2:14]

参加物

5

反応物 3

HCID 7761Diethyl MalonateHCID 707041-Pentene, 5-bromo-HCID 5360545Sodium

生成物 1

HCID 361718Diethyl 2-pent-4-enylpropanedioate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 300 mL of ethanol are added 5 g of sodium spheres and after a clear solution is obtained, 32.1 g of diethyl malonate is added in one portion. After 1 hour at room temperature, 15 g of 5-bromopent-1-ene is added and the reaction mixture is stirred at room temperature for 16 hours. The reaction mixture is evaporated to dryness and the residue is distilled under high vacuum to obtain diethyl pent-4-enylmalonate.

後処理

  1. customafter a clear solution is obtained
  2. customThe reaction mixture is evaporated to dryness
  3. distillationthe residue is distilled under high vacuum

出典と根拠

ORDレコード
ord-c794d2b781404eb9bf90b823205e2353
出典データセット
uspto-grants-1991_06
特許番号
US05025025

関連ノート

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