Pyridine → 1-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE

HRID 1505647ノート

反応式

HRID 1505647 の反応式
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[BH4-].[Na+]>C(#N)C>[CH2:1]([N:9]1[CH2:10][CH:11]=[CH:12][CH2:13][CH2:14]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 7498Benzyl BromideHCID 4311764Sodium borohydride

生成物 1

HCID 64215731-BENZYL-1,2,3,6-TETRAHYDROPYRIDINE

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
71 °C

実験手順

2.4 mL of benzyl bromide (20 mmol) was added dropwise over an hour to a solution of 1.6 mL of pyridine in 5 mL of acetonitrile. Then reaction mixture was heated at 70 to 72° C. for 3 hours. Solvent was removed under reduced pressure and the residue was dissolved in 16 mL of ethanol. 1.1 g of sodium borohydride (30 mmol) was added in small portions over 30 minutes. After stirring for 24 hs reaction mixture was carefully quenched with 50 mL of water and solvents were removed in vacuo. The residue was portioned between ethyl acetate and 2M NaOH solution. Organic extracts were washed with brine, dried over MgSO4 and evaporated to afford crude 3.36 g of crude 1-benzyl-1,2,3,6-tetrahydropyridine which was used in the next step without purification.

後処理

  1. customThen reaction mixture
  2. customSolvent was removed under reduced pressure
  3. dissolutionthe residue was dissolved in 16 mL of ethanol
  4. customwas carefully quenched with 50 mL of water and solvents
  5. customwere removed in vacuo
  6. washOrganic extracts were washed with brine
  7. dry with materialdried over MgSO4
  8. customevaporated

出典と根拠

ORDレコード
ord-541a61fa2f884180bc138b5687b9eb3f
出典データセット
uspto-grants-2015_12
特許番号
US09216993B2

反応ノート

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