Benzylamine → 6-(Benzylamino)-1-isopropyl-3,3-dimethylindolin-2-one

HRID 1507576ノート

反応式

HRID 1507576 の反応式
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:16])([CH3:15])[C:7](=[O:14])[N:8]2[CH:11]([CH3:13])[CH3:12])=[CH:4][CH:3]=1.C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1.CC(C)([O-])C.[Na+].[CH2:69]([NH2:76])[C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=1.C([O-])([O-])=O.[Na+].[Na+]>C1COCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C(Cl)(Cl)Cl.[Pd].[Pd]>[CH2:69]([NH:76][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:16])([CH3:15])[C:7](=[O:14])[N:8]2[CH:11]([CH3:13])[CH3:12])=[CH:4][CH:3]=1)[C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=1

参加物

8

反応物 5

HCID 7504BenzylamineHCID 10340Sodium CarbonateHCID 634876Binap, (A+-)-HCID 23676156Sodium t-butoxideHCID 900463286-Bromo-1-isopropyl-3,3-dimethyl-1,3-dihydro-indol-2-one

生成物 1

HCID 900477036-(Benzylamino)-1-isopropyl-3,3-dimethylindolin-2-one

試薬・触媒・溶媒 2

HCID 11029508Palladium, tris[mu-[(1,2-eta:4,5-eta)-(1E,4E)-1,5-diphenyl-1,4-pentadien-3-one]]di-, compd. with trichloromethane (1:1)触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

To a solution of 6-bromo-1-isopropyl-3,3-dimethylindolin-2-one (1.99 g, 7.08 mmol, 70%) in THF (20.0 ml) was added BINAP (227 mg, 354 μmol) and sodium tert-butoxide (1.74 g, 17.7 mmol), tris(dibenzylideneacetone)dipalladium(0) chloroform adduct (378 mg, 354 μmol) and benzylamine (766 mg, 782 μl, 7.08 mmol) under an argon atmosphere. The reaction mixture was heated to 70° C. for 18 hours. An aqueous solution of Na2CO3 was added to the reaction mixture at room temperature, the aqueous phase was extracted with tert-butyl methyl ether, the combined organic phases were dried over sodium sulfate, the solvent was evaporated and the residue purified by silica gel chromatography using ethyl acetate/heptane as eluent. The title compound was obtained as yellow foam (1.60 g).

後処理

  1. extractionthe aqueous phase was extracted with tert-butyl methyl ether
  2. dry with materialthe combined organic phases were dried over sodium sulfate
  3. customthe solvent was evaporated
  4. customthe residue purified by silica gel chromatography

出典と根拠

ORDレコード
ord-5151a38d76b04f15b799e418c7f59db9
出典データセット
uspto-grants-2015_12
特許番号
US09221816B2

反応ノート

読み込み中…