Hydrogen Bromide → HCID 67379187、化合物

HRID 1517533ノート

反応式

HRID 1517533 の反応式
[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][C:6]=1[O:14][CH3:15])([CH3:4])([CH3:3])[CH3:2].[OH-:16].[Na+].[CH2:18]1C(=O)N(Br)C(=O)C1.[BrH:26].OS(O)(=O)=O>O.CO>[CH3:18][O:16][C:9](=[O:10])[C:8]1[CH:7]=[C:6]([O:14][CH3:15])[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:13][C:12]=1[Br:26]

参加物

8

反応物 5

HCID 260Hydrogen BromideHCID 1118Sulfuric AcidHCID 14798Sodium Hydroxide2 回HCID 67184N-bromobutanimide2 回HCID 127397584-tert-Butyl-3-methoxybenzoic acid

生成物 1

HCID 67379187HCID 67379187、化合物収率 85%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

反応条件

温度
70 °C

実験手順

step 1—To a suspension of 4-tert-butyl-3-methoxybenzoic acid (3.00 g, 14.4 mmol, CASRN 79822-46-1) in H2O (30 mL) was added solid NaOH (1.21 g, 30.2 mmol). NBS (2.81 g, 15.8 mmol) was added in several portions over 10 min. The reaction mixture was stirred at RT for 1 h before additional NaOH (0.12 g, 3.0 mmol) and NBS (0.28 g, 1.6 mmol) were added. After stirring for an additional 1 h, the reaction mixture was acidified with 48% HBr, diluted with H2O then thrice extracted with Et2O. The combined extracts were washed sequentially with 10% aqueous Na2S2O3 and H2O, dried (MgSO4), filtered and concentrated under reduced pressure to afford a pale yellow solid which was dissolved in MeOH (50 mL) and con H2SO4 (5 mL) was slowly added. The reaction mixture was heated at 70° C. for 3 h, cooled to RT overnight then concentrated under reduced pressure. The residue was diluted with H2O and thrice extracted with Et2O. The combined extracts were washed with sequentially 1.0 M aq NaOH and H2O, dried (MgSO4), filtered and concentrated under reduced pressure to afford 3.7 g (85%) of 2-bromo-4-tert-butyl-5-methoxybenzoic acid methyl ester (64, CASRN 911115-95-2)

後処理

  1. additionwere added
  2. extractionthrice extracted with Et2O
  3. washThe combined extracts were washed sequentially with 10% aqueous Na2S2O3 and H2O
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customto afford a pale yellow solid which
  8. temperaturecooled to RT overnight
  9. concentrationthen concentrated under reduced pressure
  10. additionThe residue was diluted with H2O and thrice
  11. extractionextracted with Et2O
  12. washThe combined extracts were washed with sequentially 1.0 M aq NaOH and H2O
  13. dry with materialdried (MgSO4)
  14. filtrationfiltered
  15. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-263fbb3ed63f46a683ec744bdf79b355
出典データセット
uspto-grants-2012_07
特許番号
US08232271B2

反応ノート

読み込み中…