Sodium Chloride → N-(2,2-Dimethoxyethyl)-2-propenamide

HRID 1584510ノート

反応式

HRID 1584510 の反応式
[OH-].[Na+].[CH3:3][O:4][CH:5]([O:8][CH3:9])[CH2:6][NH2:7].[C:10](Cl)(=[O:13])[CH:11]=[CH2:12].[Cl-].[Na+]>O.OC1CC(C)(C)[NH+]([O-])C(C)(C)C1>[CH3:3][O:4][CH:5]([O:8][CH3:9])[CH2:6][NH:7][C:10](=[O:13])[CH:11]=[CH2:12]

参加物

7

反応物 4

HCID 5234Sodium ChlorideHCID 13140Acryloyl chlorideHCID 14798Sodium Hydroxide2 回HCID 89728Aminoacetaldehyde dimethyl acetal

生成物 1

HCID 9898899N-(2,2-Dimethoxyethyl)-2-propenamide収率 81.7%

試薬・触媒・溶媒 2

HCID 116079992,2,6,6-tetramethyl-4-hydroxypiperidine-N-oxide触媒HCID 962Water溶媒

実験手順

40 g (1.0 mol) of sodium hydroxide are dissolved in 100 g of water and 200 g of ice in a 1 litre reactor fitted with stirring and cooling means. The sodium hydroxide solution is cooled to 10° C., and 105.1 g (1.0 mol) of aminoacetaldehyde dimethyl acetal and 10 mg of the inhibitor 4-hydroxy-2,2,6,6-tetrarnethylpiperidine 1-oxide are added. 99.5 g (1.1 mol) of acryloyl chloride are slowly added to this solution at 10° C. over the course of 2 hours. The pH drops slowly and is finally set to pH=7. Amine is no longer present according to GC. The reaction mixture is saturated with sodium chloride and extracted three times with 200 ml of tert-butyl methyl ether. The organic phase is dried, filtered and evaporated on a rotary evaporator. The resultant oil is extracted three times with petroleum ether and subsequently re-dried on a rotary evaporator, giving 130 g of acrylamidoacetaldehyde dimethyl acetal (81% of theory) as an oil. The product is 99% pure according to GC. ##STR29##

後処理

  1. temperaturecooling means
  2. extractionextracted three times with 200 ml of tert-butyl methyl ether
  3. customThe organic phase is dried
  4. filtrationfiltered
  5. customevaporated on a rotary evaporator
  6. extractionThe resultant oil is extracted three times with petroleum ether
  7. customsubsequently re-dried on a rotary evaporator

出典と根拠

ORDレコード
ord-9629e37cf3c240cc86c1b4dfe34b6af6
出典データセット
uspto-grants-1999_08
特許番号
US05932674

反応ノート

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