Aniline → Benzenesulfonamide, 4-methyl-N-phenyl-

HRID 1587544

反応式

HRID 1587544 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]1([CH3:18])[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1>N1C=CC=CC=1>[CH3:18][C:8]1[CH:13]=[CH:12][C:11]([S:14]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)(=[O:16])=[O:15])=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 6115AnilineHCID 73974-Toluenesulfonyl chloride

生成物 1

HCID 2456Benzenesulfonamide, 4-methyl-N-phenyl-

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
5 °C

実験手順

Dissolve aniline (930 mg, 10 mmol) in anhydrous pyridine (25 mL) and cool to 5° C. Add, by dropwise addition, p-toluenesulfonyl chloride (2.1 g, 11 mmol) and stir overnight. Partition between water and ethyl acetate and separate the organic phase. Wash the organic phase with cold 1N hydrochloric acid, saturated sodium hydrogen carbonate and brine. Dry (MgSO4) and evaporate the solvent in vacuo to give the title compound.

後処理

  1. customPartition between water and ethyl acetate
  2. customseparate the organic phase
  3. washWash the organic phase with cold 1N hydrochloric acid, saturated sodium hydrogen carbonate and brine
  4. dry with materialDry (MgSO4)
  5. customevaporate the solvent in vacuo

出典と根拠

ORDレコード
ord-17afee4eb84643fa9f4983b8a056dfdb
出典データセット
uspto-grants-1993_06
特許番号
US05217964

関連ノート

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