Water → Ethyl 4-oxo-3,4-dihydro-2H-pyran-2-carboxylate

HRID 1594820

反応式

HRID 1594820 の反応式
[CH3:1][O:2][CH:3]=[CH:4][C:5]([O:7][Si](C)(C)C)=[CH2:6].[C:12]([O:16][CH2:17][CH3:18])(=[O:15])C=O.O.FC(F)(F)C(O)=O>C1COCC1>[CH2:17]([O:16][C:12]([CH:1]1[CH2:6][C:5](=[O:7])[CH:4]=[CH:3][O:2]1)=[O:15])[CH3:18]

参加物

6

反応物 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 70211Ethyl oxoacetateHCID 1010511-Methoxy-3-trimethylsilyloxy-1,3-butadiene

生成物 1

HCID 22495097Ethyl 4-oxo-3,4-dihydro-2H-pyran-2-carboxylate収率 102.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

ZnCl (0.63 g, 4.6 mmol) was dissolved in anhydrous THF (15 mL) and added to a solution of 1-methoxy-3-(trimethylsilyloxy)-1,3-butadiene (7.94 g, 46.0 mmol) and ethyl glyoxalate (7.05 g, 69.0 mmol) in totuene (30 mL) at room temperature. After stirring for 30 minutes, water (30 mL) and TFA (trifluoracetic acid) (2 mL) were added and the mixture was stirred vigorously for 20 min. After concentration, the residue was partitioned between EtOAc (200 mL) and water (100 mL). The separated organic layer was washed with brine, dried over sodium sulfate, and concentrated to give 8.0 g (100%) of brown oil which was carried to the next step without further purification. 1H NMR (CDCl3) δ 1.30 (t, 3H), 2.85 (d, 2H), 4.26 (q 2H), 5.00 (t, 1H), 5.48 (d, 1H), 7.39 (d, 1H).

後処理

  1. stirringthe mixture was stirred vigorously for 20 min
  2. concentrationAfter concentration
  3. customthe residue was partitioned between EtOAc (200 mL) and water (100 mL)
  4. washThe separated organic layer was washed with brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-b2ac62865fb14db3857ee52e2283060a
出典データセット
uspto-grants-2001_09
特許番号
US06284764B1

関連ノート

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