3-Methoxyphenol → 1,3-Dimethyl-4-(m-methoxyphenyloxy)-benzene

HRID 1605170

反応式

HRID 1605170 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5](Br)=[C:4]([CH3:9])[CH:3]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[CH:16][CH:17]=1.CN(C)C(=O)N(C)C.CN1CCCC1=O>O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:18][C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([O:11][CH3:10])[CH:13]=2)=[C:4]([CH3:9])[CH:3]=1

参加物

6

反応物 4

HCID 90073-MethoxyphenolHCID 12437TetramethylureaHCID 13387N-methyl-2-pyrrolidoneHCID 68503Benzene, 1-bromo-2,4-dimethyl-

生成物 1

HCID 215496571,3-Dimethyl-4-(m-methoxyphenyloxy)-benzene

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1,3-dimethyl-4-bromobenzene, 10.5 g. of m-methoxyphenol, 4.65 g. of cuprous oxide, 40 ml. of tetramethylurea, and 75 ml. of N-methylpyrrolidone is stirred at 165° for 96 hours. The resultant mixture is diluted with water and extracted with methylene chloride. The methylene chloride extracts are chromatographed on 300 g. of alumina with gradient elution using hexane:ether to give 1,3-dimethyl-4-(m-methoxyphenyloxy)-benzene.

後処理

  1. extractionextracted with methylene chloride
  2. customThe methylene chloride extracts are chromatographed on 300 g
  3. washof alumina with gradient elution

出典と根拠

ORDレコード
ord-6b639ce2671f4045b8a7ddbf95e838ee
出典データセット
uspto-grants-1976_04
特許番号
US03949084

関連ノート

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