Water → 4,4-Ethylenedioxy-4-phenylbutyl bromide

HRID 1607402

反応式

HRID 1607402 の反応式
[CH2:1]1[CH2:15][O:14][C:3]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)([CH2:4][CH2:5][CH2:6]O)[O:2]1.C(N1C=CN=C1)(N1C=CN=C1)=O.C([Br:31])C=C.O>C(#N)C>[CH2:1]1[CH2:15][O:14][C:3]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)([CH2:4][CH2:5][CH2:6][Br:31])[O:2]1

参加物

6

反応物 4

HCID 962WaterHCID 7841Allyl bromideHCID 682631,1'-CarbonyldiimidazoleHCID 223445572-(3-Hydroxypropyl)-2-phenyl-1,3-dioxolane

生成物 1

HCID 147642024,4-Ethylenedioxy-4-phenylbutyl bromide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 1.2 g of the alcohol compound obtained in 20 ml of acetonitrile were added 1.2 g of 1,1'-carbonyldiimidazole and 2.5 ml of allyl bromide. The mixture was stirred for 2 hours at room temperature and then heated under reflux for 1.5 hours. After cooling, water was added to the reaction mixture, and the mixture was extracted with diethyl ether. The ethereal layer was washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 1.1 g of 4,4-ethylenedioxy-4-phenylbutyl bromide as colorless crystals.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 1.5 hours
  3. temperatureAfter cooling
  4. extractionthe mixture was extracted with diethyl ether
  5. washThe ethereal layer was washed with a saturated sodium chloride aqueous solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-44c9fd90b9fb4f039d1e3e3c147dc398
出典データセット
uspto-grants-1989_09
特許番号
US04863904

関連ノート

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