Water → HCID 18650307、化合物

HRID 1613129ノート

反応式

HRID 1613129 の反応式
[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([OH:9])=O.[CH3:10][O:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][C:21]=1[O:22][CH3:23])[CH2:18][CH:17]([NH2:24])[CH2:16][CH2:15]2.CCOC1N(C(OCC)=O)C2C(=CC=CC=2)C=C1.O>CC#N.CCOCC.C(Cl)(Cl)Cl>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:24][CH:17]1[CH2:16][CH2:15][C:14]2[C:19](=[CH:20][C:21]([O:22][CH3:23])=[C:12]([O:11][CH3:10])[CH:13]=2)[CH2:18]1)=[O:9]

参加物

8

反応物 4

HCID 962WaterHCID 7405L-Pyroglutamic AcidHCID 278332-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinolineHCID 98162656,7-Dimethoxy-1,2,3,4-tetrahydronaphthalen-2-amine

生成物 1

HCID 18650307HCID 18650307、化合物収率 81.6%

試薬・触媒・溶媒 3

HCID 3283Diethyl Ether溶媒HCID 6212Chloroform溶媒HCID 6342Acetonitrile溶媒

実験手順

To L-pyroglutamic acid (1 g, 7.7 mmoles) in CH3CN (80 mL), 1,2,3,4-tetrahydro-6,7-dimethoxy-2-naphtylamine (1.59 g, 7.7 mmoles) and EEDQ (2.85 g, 11 mmoles) were added under stirring. To the resulting mixture water was added till complete solubilization and the solution was kept at room temperature under stirring for 20 hours. The solvent was evapored and the residue taken up with CHCl3. Et2O was added under stirring. The solid which formed was filtered off giving 2 g of the title compound. Yield 81%.

後処理

  1. customwas kept at room temperature
  2. stirringunder stirring for 20 hours
  3. stirringunder stirring
  4. customThe solid which formed
  5. filtrationwas filtered off

出典と根拠

ORDレコード
ord-b2ae8d7cfc954e9094b0d93259be5e91
出典データセット
uspto-grants-1993_03
特許番号
US05192759

反応ノート

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