Tetrahydrofuran → 7-Hydroxychromanone

HRID 1620022

反応式

HRID 1620022 の反応式
O[C:2]1[C:3](=[O:12])[O:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.C1C[O:16]CC1>[OH-].[Pd+2].[OH-]>[OH:16][C:7]1[CH:6]=[C:5]2[C:10]([CH2:11][CH2:2][C:3](=[O:12])[O:4]2)=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 8028TetrahydrofuranHCID 136503-Hydroxycoumarin

生成物 1

HCID 2981307-Hydroxychromanone

試薬・触媒・溶媒 1

HCID 9942167Palladium hydroxide触媒

実験手順

A solution of hydroxycoumarin (2.0 g, TCI) in anhydrous THF (50 ml) was added with 10% palladium hydroxide/activated carbon (1.0 g, WAKO), and stirred at room temperature for 2 hours under hydrogen atmosphere. The atmosphere was replaced with nitrogen gas, and then the insoluble matters were removed by filtration through Celite. The solvent was evaporated under reduced pressure to obtain the title compound (2.0 g).

後処理

  1. customthe insoluble matters were removed by filtration through Celite
  2. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-42b5a6e743ec43ad98e4c4167e7422da
出典データセット
uspto-grants-2014_07
特許番号
US08772327B2

関連ノート

読み込み中…