Water → FA amoxicillin

HRID 1629636

反応式

HRID 1629636 の反応式
[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23].O.C(N=C=NCCCN(C)C)C.[CH:38]1[C:43]([NH2:44])=[CH:42][C:41]2[C:45]([O:47][C:48]3([C:58]4[CH:59]=[CH:60][C:61]([OH:63])=[CH:62][C:57]=4[O:56][C:50]4[CH:51]=[C:52]([OH:55])[CH:53]=[CH:54][C:49]3=4)[C:40]=2[CH:39]=1)=[O:46]>C(#N)C>[CH:38]1[C:43]([NH2:44])=[CH:42][C:41]2[C:45]([O:47][C:48]3([C:58]4[CH:59]=[CH:60][C:61]([OH:63])=[CH:62][C:57]=4[O:56][C:50]4[CH:51]=[C:52]([OH:55])[CH:53]=[CH:54][C:49]3=4)[C:40]=2[CH:39]=1)=[O:46].[CH3:1][C:2]1([CH3:25])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:21])[C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:22]([OH:24])=[O:23]

参加物

6

反応物 4

HCID 962WaterHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 33613Amoxicillin2 回HCID 768455-Aminofluorescein4 回

生成物 1

HCID 131731698FA amoxicillin

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Fluoresceinamine (FA; 0.0583 g) was dissolved in 1.0 ml acetonitrile to from a FA solution. Amoxicillin (0.1 g) was dissolved in 30 ml deionized water, and mixed with the aforesaid FA solution. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (0.0408 g) was added thereto and magnetically stirred at room temperature in the dark for 12 hours to make FA to graft to the carboxyl group of amoxicillin to form a fluorescent-labeled FA-amoxicillin. And, finally, the sample was freeze-dried to collect the fluorescent-labeled FA-amoxicillin.

出典と根拠

ORDレコード
ord-adb1b15315a040e0ac32635795454c18
出典データセット
uspto-grants-2014_07
特許番号
US08790695B2

関連ノート

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