Hydrochloric Acid → [(2-Bromophenyl)methyl](cyclopropylmethyl)amine

HRID 1631154ノート

反応式

HRID 1631154 の反応式
[H-].[Na+].[Br:3][C:4]1[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=1[CH2:6][NH:7][CH:8]1[CH2:10][CH2:9]1.I[CH3:16].Cl>O1CCCC1>[Br:3][C:4]1[CH:14]=[CH:13][CH:12]=[CH:11][C:5]=1[CH2:6][NH:7][CH2:8][CH:10]1[CH2:9][CH2:16]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 20120601N-[(2-bromophenyl)methyl]cyclopropanamine

生成物 1

HCID 28431311[(2-Bromophenyl)methyl](cyclopropylmethyl)amine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

53 mg of sodium hydride in 3 ml of tetrahydrofuran are added to 300 mg of (2-bromobenzyl)cyclopropylamine in 2 ml of tetrahydrofuran with ice-cooling. 207 μl of iodomethane are subsequently added, and the mixture is heated at 600 for 1 h. The mixture is allowed to cool and poured onto 20 g of ice and 5 ml of 1N hydrochloric acid, washed 4 times with 10 ml of ethyl acetate each time, and the combined organic phases are dried over sodium sulfate. After filtration, the filtrate is evaporated to dryness.

後処理

  1. temperaturecooling
  2. temperaturethe mixture is heated at 600 for 1 h
  3. temperatureto cool
  4. washwashed 4 times with 10 ml of ethyl acetate each time
  5. dry with materialthe combined organic phases are dried over sodium sulfate
  6. filtrationAfter filtration
  7. customthe filtrate is evaporated to dryness

出典と根拠

ORDレコード
ord-20c744233e1440fb86f58e54d4f462bd
出典データセット
uspto-grants-2014_07
特許番号
US08791129B2

反応ノート

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