2,6-Difluorobenzoic acid → Benzamide, 2,6-difluoro-N-methyl-

反応式

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4](O)=[O:5].[C:12](N1C=CN=C1)([N:14]1C=CN=C1)=O.Cl.CN.C(N(C(C)C)CC)(C)C>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH:14][CH3:12])=[O:5]

参加物

反応物 4

HCID 97962,6-Difluorobenzoic acid

HCID 682631,1'-Carbonyldiimidazole

HCID 81531Diisopropylethylamine

HCID 6364545Methylamine hydrochloride

生成物 1

HCID 4106176Benzamide, 2,6-difluoro-N-methyl-

実験手順

The title compound was prepared from 2,6-difluorobenzoic acid (10 g, 63.2 mmol), carbonyldiimidazole (10.26 g, 63.5 mmol), methylamine hydrochloride (4.27 g, 63.25 mmol) and diisopropylethyl amine according to the procedure used for example 84 (Step A) to give near quantitative yield of the title compound.

出典と根拠

ORDレコード: ord-87903239bff844dfb6b9479969497e88
出典データセット: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06506901B2

反応ノート

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