Diethyl Ether → 2-Propyl-4-chloro-3-methyl-pyridine

HRID 1635093ノート

反応式

HRID 1635093 の反応式
[CH2:1](I)[CH2:2][CH3:3].[Li].[Cl:6][C:7]1[CH:12]=[CH:11][N:10]=[CH:9][C:8]=1[CH3:13].CCOCC>C1COCC1.CCCCCC.C(OCC)(=O)C>[CH2:1]([C:9]1[C:8]([CH3:13])=[C:7]([Cl:6])[CH:12]=[CH:11][N:10]=1)[CH2:2][CH3:3]

参加物

7

反応物 4

HCID 3283Diethyl EtherHCID 336431-IodopropaneHCID 27577094-Chloro-3-methylpyridineHCID 3028194Lithium2 回

生成物 1

HCID 186758642-Propyl-4-chloro-3-methyl-pyridine

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 21226206Ethyl acetate hexane溶媒

反応条件

温度
40 °C

実験手順

To a solution of propyl iodide (12.7 g) in THF (10 ml) is added lithium (0.45 g) and the reaction is allowed to stir at room temperature until complete dissolution of the lithium. 4-Chloro-3-methyl-pyridine (9.5 g) is then added and the mixture allowed to stir at 40° C. for 4 hours. After cooling at room temperature, ether is added and the organic phase washed with water. After removal of the solvent the desired product is obtained by chromatography using hexane/ether 9/1 as solvent.

後処理

  1. temperatureAfter cooling at room temperature
  2. washthe organic phase washed with water
  3. customAfter removal of the solvent the desired product
  4. customis obtained by chromatography

出典と根拠

ORDレコード
ord-9b2234da1006484a9b09cfdc7d89fb83
出典データセット
uspto-grants-2003_01
特許番号
US06509349B1

反応ノート

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