p-Toluenesulfonic acid → HCID 19833158、化合物

HRID 1639373ノート

反応式

HRID 1639373 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[CH2:8][C:7](=O)[CH2:6][CH2:5]2.C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[CH:8]=[C:7]([N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1)[CH2:6][CH2:5]2

参加物

5

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 31268PyrrolidineHCID 44528536,7-Dichloro-2-tetralone

生成物 1

HCID 19833158HCID 19833158、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

9.00 g (0.042 mol) of 6,7-dichloro-3,4-dihydro-2(1H)-naphthalenone and 0.3 g of p-toluenesulfonic acid are dissolved in 200 ml of pyridine, 3.5 ml (0.042 mol) of pyrrolidine are added dropwise and the mixture is boiled under reflux for 2 hours. Distillation of the solvent in a vacuum, addition of 200 ml of ether and filtering off the crystals formed yields 1-(6,7-dichloro-3,4-dihydro-2naphthyl)pyrrolidine with melting point 141°-142°.

後処理

  1. temperatureunder reflux for 2 hours
  2. distillationDistillation of the solvent
  3. additionin a vacuum, addition of 200 ml of ether
  4. filtrationfiltering off the crystals
  5. customformed

出典と根拠

ORDレコード
ord-a7aaa6854d2a43b4b2cb450b6c4f03be
出典データセット
uspto-grants-1989_11
特許番号
US04883815

反応ノート

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