反応式
C([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)([OH:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>[Pd].CO.C(Cl)(Cl)Cl>[N:17]1[CH:18]=[CH:19][CH:20]=[C:15]([C:11]2([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:16]=1参加物
6
反応条件
- 温度
- 68 °C
実験手順
(Apparatus: 1 I three-necked flask with condenser) Palladium on charcoal (10%, catalytic amount) was added to a solution of 1-benzyl-4-(pyridin-3-yl)piperidin-4-ol (32 g) in methanol (220 ml), followed by ammonium formate solution (22.7 g in 50 ml of water). The reaction mixture was refluxed at 68° C. overnight. Thin layer chromatography control: 20% methanol in chloroform. The mixture was filtered over Celite and the filtrate was concentrated in vacuo. The residue was washed with acetone (100 ml) in order to obtain the desired compound in a pure form. Yield: 17.3 g (81%)
後処理
- filtrationThe mixture was filtered over Celite
- concentrationthe filtrate was concentrated in vacuo
- washThe residue was washed with acetone (100 ml) in order
出典と根拠
- ORDレコード
- ord-e09f3ab50bd2422d8bb92ccb82c28e45
- 出典データセット
- uspto-grants-2012_02
- 特許番号
- US08119805B2
関連ノート
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